{"id":14067,"date":"2019-05-01T10:40:45","date_gmt":"2019-05-01T10:40:45","guid":{"rendered":"https:\/\/staging.awgp.pt\/testes\/?p=14067"},"modified":"2025-04-22T15:26:59","modified_gmt":"2025-04-22T15:26:59","slug":"temporary-title-14067","status":"publish","type":"post","link":"https:\/\/staging.awgp.pt\/testes\/temporary-title-14067\/","title":{"rendered":"Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy?"},"content":{"rendered":"<style type=\"text\/css\"><\/style>\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"14067\" class=\"elementor elementor-14067\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5d1ee0ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5d1ee0ce\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2badf438\" data-id=\"2badf438\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-20aae24 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"20aae24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-00306ac elementor-widget elementor-widget-text-editor\" data-id=\"00306ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Pediatr Hematol Oncol.\u00a02019 May;36(4):211-221. doi: 10.1080\/08880018.2019.1621970. Epub 2019 Jul 9<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e27bd3e elementor-widget elementor-widget-heading\" data-id=\"e27bd3e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2255b76 elementor-widget elementor-widget-text-editor\" data-id=\"2255b76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Jain R.<sup>1<\/sup>, Trehan A.<sup>1<\/sup>, Bansal D.<sup>1,2<\/sup>, Varma N.<sup>2<\/sup><\/p><p><strong>Abstract<\/strong><\/p><p>Aplastic\u00a0anemia\u00a0(AA) is an uncommon disorder in\u00a0children, with hematopoietic stem cell transplant being the 1st line therapy; immunosuppressive therapy (IST) is the alternative therapy and is the most commonly used modality of treatment. There is paucity of data from the developing countries regarding treatment outcome with IST. We aimed to assess the outcome of IST in\u00a0children\u00a0with AA. Data for 43\u00a0children\u00a0treated with IST from January 2012 to January 2017 (5 years) were retrieved from clinic records. IST included equine antithymocyte globulin (ATG) along with cyclosporine A. Complete response, partial response and nonresponse was seen in 9 (21%), 14 (32.5%) and 20(46.5%) patients, respectively. The median time to best response in the whole cohort was 19.1\u2009months. However, complete response occurred nearly 2-year post-IST. There was no difference in outcome related to severity of AA, the presence of PNH clone, higher ALC or different available brands of ATG. There was a significantly better rate of response (<em>p<\/em> value: .03) at 6\u2009months in patients who went on to achieve a CR vs patients who achieved a final PR only. An overall response rate, including partial and complete response, of 53.5% was seen in our cohort with a 3-year OS of 63%. This is not at par to the outcome reported from developed nations. The available brands of ATG were similar in terms of response kinetics as well as survival. A delayed time to complete response with prolonged requirement of cyclosporine therapy was seen in the cohort.<\/p><p><strong>KEYWORDS<\/strong>: Antithymocyte globulin; aplastic anemia; immunosuppressive therapy<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4cb847 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d4cb847\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm elementor-animation-pulse-shrink\" href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/08880018.2019.1621970?journalCode=ipho20\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Pediatric Hematology and Oncology<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5596f7b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5596f7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pediatr Hematol Oncol.\u00a02019 May;36(4):211-221. doi: 10.1080\/08880018.2019.1621970. Epub 2019 Jul 9 Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy? Jain R.1, Trehan A.1, Bansal D.1,2, Varma N.2 Abstract Aplastic\u00a0anemia\u00a0(AA) is an uncommon disorder in\u00a0children, with hematopoietic stem cell transplant being the 1st line therapy; immunosuppressive therapy (IST) is the alternative therapy and is the most commonly used modality&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,97],"tags":[134,99,145,143,144],"class_list":["post-14067","post","type-post","status-publish","format-standard","hentry","category-anemia-na-crianca","category-artigo-cientifico","tag-anemia-in-children","tag-anemia-na-crianca","tag-antithymocyte-globulin","tag-aplastic-anemia","tag-immunosuppressive-therapy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy? - AWGP - Testes<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy? - AWGP - Testes\" \/>\n<meta property=\"og:description\" content=\"Pediatr Hematol Oncol.\u00a02019 May;36(4):211-221. doi: 10.1080\/08880018.2019.1621970. Epub 2019 Jul 9 Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy? Jain R.1, Trehan A.1, Bansal D.1,2, Varma N.2 Abstract Aplastic\u00a0anemia\u00a0(AA) is an uncommon disorder in\u00a0children, with hematopoietic stem cell transplant being the 1st line therapy; immunosuppressive therapy (IST) is the alternative therapy and is the most commonly used modality...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/staging.awgp.pt\/testes\/temporary-title-14067\/\" \/>\n<meta property=\"og:site_name\" content=\"AWGP - Testes\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/anemiawgp\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-05-01T10:40:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-22T15:26:59+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo estimado de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/temporary-title-14067\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/temporary-title-14067\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/#\\\/schema\\\/person\\\/692d74175ec69da279706f08b0c063ee\"},\"headline\":\"Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy?\",\"datePublished\":\"2019-05-01T10:40:45+00:00\",\"dateModified\":\"2025-04-22T15:26:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/temporary-title-14067\\\/\"},\"wordCount\":282,\"publisher\":{\"@id\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/#organization\"},\"keywords\":[\"anemia in children\",\"Anemia na crian\u00e7a\",\"antithymocyte globulin\",\"aplastic anemia\",\"immunosuppressive therapy\"],\"articleSection\":[\"Anemia na Crian\u00e7a\",\"Artigo cientifico\"],\"inLanguage\":\"pt-PT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/temporary-title-14067\\\/\",\"url\":\"https:\\\/\\\/staging.awgp.pt\\\/testes\\\/temporary-title-14067\\\/\",\"name\":\"Aplastic\u00a0anemia\u00a0in\u00a0children: How good is immunosuppressive therapy? 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