{"id":14746,"date":"2019-01-06T14:55:47","date_gmt":"2019-01-06T14:55:47","guid":{"rendered":"https:\/\/staging.awgp.pt\/testes\/?p=14746"},"modified":"2025-04-22T15:24:58","modified_gmt":"2025-04-22T15:24:58","slug":"a-model-based-cost-effectiveness-analysis-of-patient-blood-management","status":"publish","type":"post","link":"https:\/\/staging.awgp.pt\/testes\/a-model-based-cost-effectiveness-analysis-of-patient-blood-management\/","title":{"rendered":"A model-based cost-effectiveness analysis of Patient Blood Management"},"content":{"rendered":"<style type=\"text\/css\"><\/style>[cmsmasters_row data_padding_bottom=&#8221;50&#8243; data_padding_top=&#8221;0&#8243; data_bg_parallax_ratio=&#8221;0.5&#8243; data_bg_size=&#8221;cover&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_position=&#8221;top center&#8221; data_color=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_top_style=&#8221;default&#8221; data_padding_right=&#8221;3&#8243; data_padding_left=&#8221;3&#8243; data_width=&#8221;boxed&#8221;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;]<\/p>\n<p><i>Blood Transfus 2019; <\/i><b><i>17<\/i><\/b><i>: 16-26 <\/i>DOI 10.2450\/2018.0213-17<\/p>\n<h2 class=\"p2\"><b>A model-based cost-effectiveness analysis of Patient Blood Management <\/b><\/h2>\n<p class=\"p3\">Adina Kleiner\u00fcschkamp<span class=\"s2\">1<\/span>, Patrick Meybohm<span class=\"s2\">1<\/span>, Niels Straub<span class=\"s2\">2<\/span>, Kai Zacharowski<span class=\"s2\">1<\/span>, Suma Choorapoikayil<span class=\"s2\">1<\/span><\/p>\n<p class=\"p4\"><sup><span class=\"s3\"><i>1<\/i><\/span><i>Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt; <\/i><span class=\"s3\"><i>2<\/i><\/span><i>Institute of Market Research, Statistics and Prognosis, Munich, Germany<\/i><\/sup><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p2\"><b>Background. <\/b>Patient blood management (PBM) is a multidisciplinary concept focused on the management of anaemia, minimisation of iatrogenic blood loss and rational use of allogeneic blood products. The aims of this study were: (i) to analyse post-operative outcome in patients with liberal <i>vs <\/i>restrictive exposure to allogeneic blood products and (ii) to evaluate the cost-effectiveness of PBM in patients undergoing surgery.<\/p>\n<p class=\"p2\"><b>Materials and methods. <\/b>A systematic literature review and meta-analysis were performed to compare post-operative complications in predominantly non-transfused patients (restrictive transfusion group) and patients who received one to three units of red blood cells (liberal transfusion group). Outcome measures included sepsis with\/without pneumonia, acute renal failure, acute myocardial infarction and acute stroke. In a second step, a health economic model was developed to calculate cost-effectiveness of PBM (PBM-arm <i>vs <\/i>control-arm) for simulated cohorts of 10,000 cardiac and non-cardiac surgical patients based on the results of the meta-analysis and costs.<\/p>\n<p class=\"p2\"><b>Results. <\/b>Out of 478 search results, 22 studies were analysed in the meta-analysis. The pooled relative risk of any complication in the restrictive transfusion group was 0.43 for non-cardiac and 0.34 for cardiac surgical patients. In the simulation model, PBM was related to reduced complications (1,768 <i>vs <\/i>1,245) and complication-related deaths (411 <i>vs <\/i>304) compared to standard care. PBM-related costs of therapy exceeded costs of the control arm by \u20ac 150 per patient. However, total costs, including hospitalisation, were higher in the control-arm for both non-cardiac (\u20ac 2,885.11) and cardiac surgery patients (\u20ac 1,760.69). The incremental cost-effectiveness ratio including hospitalisation showed savings of \u20ac 30,458 (non-cardiac and cardiac surgery patients) for preventing one complication and \u20ac 128,023 (non-cardiac and cardiac surgery patients) for prevention of one complication-related death in the PBM-arm.<\/p>\n<p class=\"p2\"><b>Discussion. <\/b>Our results indicate that PBM may be associated with fewer adverse clinical outcomes compared to control management and may, thereby, be cost-effective.<\/p>\n<p class=\"p2\"><b>Keywords: <\/b>patient blood management, transfusion, outcome, cost-effectiveness-analysis, health economics.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/cmsmasters_text][cmsmasters_text animation_delay=&#8221;0&#8243;]<\/p>\n<p>[pdf-embedder url=&#8221;https:\/\/staging.awgp.pt\/testes\/wp-content\/uploads\/2019\/09\/A-model-based-cost-effectiveness-analysis-of-patient-blood-management.pdf&#8221; title=&#8221;A model-based cost-effectiveness analysis of patient blood management&#8221;]<\/p>\n<p>[\/cmsmasters_text][\/cmsmasters_column][\/cmsmasters_row]\n","protected":false},"excerpt":{"rendered":"<p>[cmsmasters_row data_padding_bottom=&#8221;50&#8243; data_padding_top=&#8221;0&#8243; data_bg_parallax_ratio=&#8221;0.5&#8243; data_bg_size=&#8221;cover&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_position=&#8221;top center&#8221; data_color=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_top_style=&#8221;default&#8221; data_padding_right=&#8221;3&#8243; data_padding_left=&#8221;3&#8243; data_width=&#8221;boxed&#8221;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;] Blood Transfus 2019; 17: 16-26 DOI 10.2450\/2018.0213-17 A model-based cost-effectiveness analysis of Patient Blood Management Adina Kleiner\u00fcschkamp1, Patrick Meybohm1, Niels Straub2, Kai Zacharowski1, Suma Choorapoikayil1 1Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt;&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[97,111],"tags":[],"class_list":["post-14746","post","type-post","status-publish","format-standard","hentry","category-artigo-cientifico","category-patient-blood-management"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - 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