{"id":15112,"date":"2018-10-01T10:33:32","date_gmt":"2018-10-01T10:33:32","guid":{"rendered":"https:\/\/staging.awgp.pt\/testes\/?p=15112"},"modified":"2025-04-22T15:23:55","modified_gmt":"2025-04-22T15:23:55","slug":"temporary-title-15112","status":"publish","type":"post","link":"https:\/\/staging.awgp.pt\/testes\/temporary-title-15112\/","title":{"rendered":"Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh"},"content":{"rendered":"<style type=\"text\/css\"><\/style>[cmsmasters_row data_padding_bottom=&#8221;50&#8243; data_padding_top=&#8221;0&#8243; data_bg_parallax_ratio=&#8221;0.5&#8243; data_bg_size=&#8221;cover&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_position=&#8221;top center&#8221; data_color=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_top_style=&#8221;default&#8221; data_padding_right=&#8221;3&#8243; data_padding_left=&#8221;3&#8243; data_width=&#8221;boxed&#8221;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;]<\/p>\n<p class=\"cit\"><span role=\"menubar\">J Nutr.<\/span>\u00a02018 Oct 1;148(10):1615-1624. doi: 10.1093\/jn\/nxy161.<\/p>\n<h2>Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh.<\/h2>\n<p class=\"auths\">Matias SL<sup>1<\/sup>,\u00a0Mridha MK<sup>1,<\/sup><sup>2<\/sup>,\u00a0Young RT<sup>1<\/sup>,\u00a0Hussain S<sup>3<\/sup>,\u00a0Dewey KG<sup>1<\/sup>.<\/p>\n<div class=\"afflist\">\n<p><strong><span class=\"ui-ncbitoggler-master-text\">Author information<\/span><\/strong><\/p>\n<dl class=\"ui-ncbi-toggler-slave-open ui-ncbitoggler ui-ncbitoggler-slave-open\" aria-hidden=\"false\">\n<dt><sup>1 &#8211; Department of Nutrition, University of California, Davis, Davis, CA.<\/sup><\/dt>\n<dt><sup>2 &#8211; James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh.<\/sup><\/dt>\n<dt><sup>3 &#8211; Consultant, Dhaka, Bangladesh.<\/sup><\/dt>\n<\/dl>\n<\/div>\n<div class=\"abstr\">\n<h3>Abstract<\/h3>\n<div class=\"\">\n<p><strong>BACKGROUND: <\/strong>Maternal anemia and iron deficiency are prevalent in low- and middle-income countries.<\/p>\n<p><strong>OBJECTIVE: <\/strong>We aimed to determine the effects of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on hemoglobin (Hb), anemia, and iron status (nonprimary outcomes) at 36 weeks of gestation (women) and 6 mo postpartum (women and infants).<\/p>\n<p><strong>METHODS: <\/strong>The Rang-Din Nutrition Study, a cluster-randomized effectiveness trial, enrolled 4011 Bangladeshi pregnant women at \u226420 weeks of gestation to receive either daily LNS-PL (20 mg Fe) during pregnancy and the first 6 mo postpartum, or iron and folic acid (IFA, 60 mg Fe\u00a0+\u00a0400 \u00b5g folic acid) daily during pregnancy and every other day during the first 3 mo postpartum. Biochemical measurements from a subsample of women (n\u00a0=\u00a01128) and their infants (n\u00a0=\u00a01117) included Hb (g\/L), serum ferritin (\u00b5g\/L), and soluble transferrin receptor (sTfR; mg\/L). Anemia was defined as maternal Hb &lt;110 g\/L at 36 weeks of gestation, &lt;120 g\/L at 6 mo postpartum, or infant Hb &lt;105 g\/L; iron deficiency (ID) was defined as ferritin &lt;12 \u00b5g\/L or elevated sTfR (&gt;8.3 mg\/L for women and &gt;11 mg\/L for infants).<\/p>\n<p><strong>RESULTS: <\/strong>Compared with the IFA group, women in the LNS-PL group had lower ferritin (-6.2 \u00b5g\/L; P\u00a0&lt;\u00a00.001) and higher sTfR concentrations (+0.5 mg\/L; P\u00a0&lt;\u00a00.001), and higher risk of ID (OR\u00a0=\u00a01.93; P\u00a0&lt;\u00a00.05) at 36 weeks of gestation but not at 6 mo postpartum, whereas no consistent differences were observed for Hb or anemia. Among infants at 6 mo, there were no group differences except for a lower risk of elevated sTfR (OR\u00a0=\u00a00.61; P\u00a0&lt;\u00a00.05) in the LNS-PL group than in the IFA group.<\/p>\n<p><strong>CONCLUSIONS: <\/strong>Provision of LNS-PL including a lower dose of iron than what is recommended during pregnancy resulted in differences in maternal iron status in late pregnancy that disappeared by 6 mo postpartum, and caused no undesirable effects regarding anemia or iron status of infants. This trial was registered at clinicaltrials.gov as\u00a0NCT01715038.<\/p>\n<\/div>\n<\/div>\n<p>[\/cmsmasters_text][cmsmasters_text animation_delay=&#8221;0&#8243;]<\/p>\n<p>[pdf-embedder url=&#8221;https:\/\/staging.awgp.pt\/testes\/wp-content\/uploads\/2019\/10\/Daily-maternal-lipid-based-nutrient-suplementation-with-20mg-iron-compared-with-iron-and-folic-acid-with-60mg-.pdf&#8221; title=&#8221;Daily maternal lipid-based nutrient suplementation with 20mg iron, compared with iron and folic acid with 60mg,&#8221;]<\/p>\n<p>[\/cmsmasters_text][\/cmsmasters_column][\/cmsmasters_row]\n","protected":false},"excerpt":{"rendered":"<p>[cmsmasters_row data_padding_bottom=&#8221;50&#8243; data_padding_top=&#8221;0&#8243; data_bg_parallax_ratio=&#8221;0.5&#8243; data_bg_size=&#8221;cover&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_position=&#8221;top center&#8221; data_color=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_top_style=&#8221;default&#8221; data_padding_right=&#8221;3&#8243; data_padding_left=&#8221;3&#8243; data_width=&#8221;boxed&#8221;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;] J Nutr.\u00a02018 Oct 1;148(10):1615-1624. doi: 10.1093\/jn\/nxy161. Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[102,97],"tags":[85,142,133,141,92,82,81,140,103,105,104],"class_list":["post-15112","post","type-post","status-publish","format-standard","hentry","category-anemia-na-gravida","category-artigo-cientifico","tag-acido-folico","tag-anemia-in-pregnancy","tag-anemia-in-woman","tag-anemia-na-gravidez","tag-anemia-na-mulher","tag-falta-de-ferro","tag-ferropenia","tag-folic-acid","tag-gravidez","tag-iron-deficiency","tag-pregnancy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh - AWGP - Testes<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Daily Maternal Lipid-Based Nutrient Supplementation with 20 mg Iron, Compared with Iron and Folic Acid with 60 mg Iron, Resulted in Lower Iron Status in Late Pregnancy but Not at 6 Months Postpartum in Either the Mothers or Their Infants in Bangladesh - AWGP - Testes\" \/>\n<meta property=\"og:description\" content=\"[cmsmasters_row data_padding_bottom=&#8221;50&#8243; data_padding_top=&#8221;0&#8243; data_bg_parallax_ratio=&#8221;0.5&#8243; data_bg_size=&#8221;cover&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_position=&#8221;top center&#8221; data_color=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_top_style=&#8221;default&#8221; data_padding_right=&#8221;3&#8243; data_padding_left=&#8221;3&#8243; data_width=&#8221;boxed&#8221;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;] J Nutr.\u00a02018 Oct 1;148(10):1615-1624. doi: 10.1093\/jn\/nxy161. 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