{"id":15199,"date":"2017-08-01T17:49:27","date_gmt":"2017-08-01T17:49:27","guid":{"rendered":"https:\/\/staging.awgp.pt\/testes\/?p=15199"},"modified":"2025-04-22T15:20:29","modified_gmt":"2025-04-22T15:20:29","slug":"effects-of-different-regimens-of-iron-prophylaxis-on-maternal-iron-status-and-pregnancy-outcome-a-randomized-control-trial","status":"publish","type":"post","link":"https:\/\/staging.awgp.pt\/testes\/effects-of-different-regimens-of-iron-prophylaxis-on-maternal-iron-status-and-pregnancy-outcome-a-randomized-control-trial\/","title":{"rendered":"Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial"},"content":{"rendered":"<style type=\"text\/css\"><\/style>[cmsmasters_row data_width=&#8221;boxed&#8221; data_padding_left=&#8221;3&#8243; data_padding_right=&#8221;3&#8243; data_top_style=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_color=&#8221;default&#8221; data_bg_position=&#8221;top center&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_size=&#8221;cover&#8221; data_bg_parallax_ratio=&#8221;0.5&#8243; data_padding_top=&#8221;0&#8243; data_padding_bottom=&#8221;50&#8243;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;]<\/p>\n<p class=\"cit\"><span role=\"menubar\">J Matern Fetal Neonatal Med.<\/span>\u00a02017 Aug;30(15):1787-1792. doi: 10.1080\/14767058.2016.1224841. Epub 2016 Sep 2.<\/p>\n<h2>Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial<\/h2>\n<p class=\"auths\">Parisi F<sup>1<\/sup>,\u00a0Berti C<sup>1<\/sup>,\u00a0Mand\u00f2 C<sup>1<\/sup>,\u00a0Martinelli A<sup>1<\/sup>,\u00a0Mazzali C<sup>2<\/sup>,\u00a0Cetin I<sup>1<\/sup>.<\/p>\n<p>&nbsp;<\/p>\n<div class=\"afflist\">\n<p><strong><span class=\"ui-ncbitoggler-master-text\">Author information<\/span><\/strong><\/p>\n<div class=\"ui-helper-reset\" aria-live=\"assertive\">\n<dl class=\"ui-ncbi-toggler-slave-open ui-ncbitoggler ui-ncbitoggler-slave-open\" aria-hidden=\"false\">\n<dt>1 &#8211; a Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, Center for Fetal Research Giorgio Pardi, Hospital Luigi Sacco, Universit\u00e0 degli Studi di Milano , Milan , Italy and.<\/dt>\n<dt>2 &#8211; b Unit of Statistics and Biometrics, Department of Biomedical and Clinical Sciences, Hospital Luigi Sacco, Universit\u00e0 degli Studi di Milano , Milan , Italy.<\/dt>\n<\/dl>\n<\/div>\n<\/div>\n<div class=\"abstr\">\n<p><strong>Abstract<\/strong><\/p>\n<div class=\"\">\n<p><strong>PURPOSE<\/strong>: Iron supplementation is associated with side effects and overload risk. We compared different regimens of iron supplementation on maternal hematological status and pregnancy outcome in a cohort of healthy pregnant women.<\/p>\n<p><strong>MATERIALS AND METHODS: <\/strong>Eighty non-anemic women with a normal singleton pregnancy were recruited at 11-13 weeks and randomized into controls (C; n\u2009=\u200920) and groups supplemented with ferrous iron 30\u2009mg (FI; n\u2009=\u200920), liposomal iron 14\u2009mg (Sideral\u00ae Pharmanutra, Pisa PI, Italy) (LI14; n\u2009=\u200920) and liposomal iron 28\u2009mg\/daily (LI28; n\u2009=\u200920) up to 6 weeks post-partum. Longitudinal maternal blood samples for iron markers were collected. Data on birth outcome were recorded. The treatment effect was evaluated using a mixed-effect regression model.<\/p>\n<p><strong>RESULTS: <\/strong>Both LI28 and LI14 groups showed significantly higher hemoglobin and ferritin concentrations compared with controls. Birth weight showed a trend to increase with supplementation, resulting in higher birth weight in the LI28 group compared with controls (3499\u2009\u00b1\u2009464.1\u2009g and 3092\u2009\u00b1\u2009469.5\u2009g, respectively, p\u2009&lt;\u20090.01).<\/p>\n<p><strong>CONCLUSIONS: <\/strong>Our data show the effectiveness of 28\u2009mg and 14\u2009mg LI on maternal anemia prevention, as previously reported with FI 40\u2009mg. LI has similar effects of higher doses of ferrous iron on maternal hematological parameters, thus allowing to reduce iron doses and side effects.<\/p>\n<\/div>\n<\/div>\n<div class=\"keywords\">\n<p><strong>KEYWORDS: <\/strong>Anemia; iron deficiency anemia; iron supplementation; liposomal iron; pregnancy<\/p>\n<\/div>\n<p>[\/cmsmasters_text][cmsmasters_button button_type=&#8221;regular&#8221; button_link=&#8221;https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/14767058.2016.1224841?journalCode=ijmf20&#8243; button_target=&#8221;blank&#8221; button_text_align=&#8221;left&#8221; button_style=&#8221;cmsmasters_but_bg_slide_left&#8221; button_font_weight=&#8221;normal&#8221; button_font_style=&#8221;normal&#8221; button_border_style=&#8221;solid&#8221; animation_delay=&#8221;0&#8243;]The Journal of Maternal-Fetal &amp; Neonatal Medicine[\/cmsmasters_button][\/cmsmasters_column][\/cmsmasters_row]\n","protected":false},"excerpt":{"rendered":"<p>[cmsmasters_row data_width=&#8221;boxed&#8221; data_padding_left=&#8221;3&#8243; data_padding_right=&#8221;3&#8243; data_top_style=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_color=&#8221;default&#8221; data_bg_position=&#8221;top center&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_size=&#8221;cover&#8221; data_bg_parallax_ratio=&#8221;0.5&#8243; data_padding_top=&#8221;0&#8243; data_padding_bottom=&#8221;50&#8243;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;] J Matern Fetal Neonatal Med.\u00a02017 Aug;30(15):1787-1792. doi: 10.1080\/14767058.2016.1224841. Epub 2016 Sep 2. Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial Parisi F1,\u00a0Berti C1,\u00a0Mand\u00f2 C1,\u00a0Martinelli A1,\u00a0Mazzali C2,\u00a0Cetin I1. &nbsp;&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[102,97],"tags":[100,82,81,103,206,237,104,238],"class_list":["post-15199","post","type-post","status-publish","format-standard","hentry","category-anemia-na-gravida","category-artigo-cientifico","tag-deficiencia-de-ferro","tag-falta-de-ferro","tag-ferropenia","tag-gravidez","tag-iron-deficiency-anemia","tag-iron-supplementation","tag-pregnancy","tag-suplemento-de-ferro"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial - AWGP - Testes<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: a randomized control trial - AWGP - Testes\" \/>\n<meta property=\"og:description\" content=\"[cmsmasters_row data_width=&#8221;boxed&#8221; data_padding_left=&#8221;3&#8243; data_padding_right=&#8221;3&#8243; data_top_style=&#8221;default&#8221; data_bot_style=&#8221;default&#8221; data_color=&#8221;default&#8221; data_bg_position=&#8221;top center&#8221; data_bg_repeat=&#8221;no-repeat&#8221; data_bg_attachment=&#8221;scroll&#8221; data_bg_size=&#8221;cover&#8221; data_bg_parallax_ratio=&#8221;0.5&#8243; data_padding_top=&#8221;0&#8243; data_padding_bottom=&#8221;50&#8243;][cmsmasters_column data_width=&#8221;1\/1&#8243;][cmsmasters_text animation_delay=&#8221;0&#8243;] J Matern Fetal Neonatal Med.\u00a02017 Aug;30(15):1787-1792. doi: 10.1080\/14767058.2016.1224841. 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